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Registro completo
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Biblioteca (s) : |
INIA La Estanzuela. |
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Fecha : |
02/03/2017 |
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Actualizado : |
07/03/2017 |
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Autor : |
GARCIA, J.P; GIANNITTI, F.; FINNIE, J.W.; MANAVIS, J. .; BEINGESSER, J.; ADAMS ,V.; ROOD, J.I.; UZAL, F.A. |
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Afiliación : |
FEDERICO GIANNITTI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
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Título : |
Comparative Neuropathology of Ovine Enterotoxemia Produced by Clostridium perfringens Type D Wild-Type Strain CN1020 and Its Genetically Modified Derivatives. |
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Fecha de publicación : |
2015 |
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Fuente / Imprenta : |
Veterinary Pathology, 2015, v.52.n.6. p.1250-1253, 2015. |
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Idioma : |
Inglés |
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Contenido : |
Abstract
Clostridium perfringens type D causes enterotoxemia in sheep and goats. The disease is mediated by epsilon toxin (ETX), which affects the cerebrovascular endothelium, increasing vascular permeability and leading to cerebral edema. In the present study, we compared the distribution and severity of the cerebrovascular changes induced in lambs by C. perfringens type D strain CN1020, its isogenic etx null mutant, and the ETX-producing complemented mutant. We also applied histochemical and immunohistochemical markers to further characterize the brain lesions induced by ETX. Both ETX-producing strains induced extensive cerebrovascular damage that did not differ significantly between each other in nature, neuroanatomic distribution, or severity. By contrast, lambs inoculated with the etx mutant or sterile, nontoxic culture medium did not develop detectable brain lesions, confirming that the neuropathologic effects observed in these infections are dependent on ETX production. Lambs treated with the wild-type and complemented strains showed perivascular and mural vascular edema, as well as serum albumin extravasation, particularly severe in the cerebral white matter, midbrain, medulla oblongata, and cerebellum. Brains of animals inoculated with the ETX-producing strains showed decreased expression of glial fibrillary acidic protein and increased expression of aquaporin-4 in the end-feet processes of the astrocytes around blood vessels. Early axonal injury was demonstrated with anti?amyloid precursor protein immunohistochemistry. Perivascular accumulation of macrophages/microglia with intracytoplasmic albumin globules was also observed in these animals. This study demonstrates that ETX is responsible for the major cerebrovascular changes in C. perfringens type D?induced disease. MenosAbstract
Clostridium perfringens type D causes enterotoxemia in sheep and goats. The disease is mediated by epsilon toxin (ETX), which affects the cerebrovascular endothelium, increasing vascular permeability and leading to cerebral edema. In the present study, we compared the distribution and severity of the cerebrovascular changes induced in lambs by C. perfringens type D strain CN1020, its isogenic etx null mutant, and the ETX-producing complemented mutant. We also applied histochemical and immunohistochemical markers to further characterize the brain lesions induced by ETX. Both ETX-producing strains induced extensive cerebrovascular damage that did not differ significantly between each other in nature, neuroanatomic distribution, or severity. By contrast, lambs inoculated with the etx mutant or sterile, nontoxic culture medium did not develop detectable brain lesions, confirming that the neuropathologic effects observed in these infections are dependent on ETX production. Lambs treated with the wild-type and complemented strains showed perivascular and mural vascular edema, as well as serum albumin extravasation, particularly severe in the cerebral white matter, midbrain, medulla oblongata, and cerebellum. Brains of animals inoculated with the ETX-producing strains showed decreased expression of glial fibrillary acidic protein and increased expression of aquaporin-4 in the end-feet processes of the astrocytes around blood vessels. Early axonal injury was demonstrated wi... Presentar Todo |
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Thesagro : |
ENFERMEDADES DE LOS ANIMALES. |
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Asunto categoría : |
-- |
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Marc : |
LEADER 02512naa a2200217 a 4500
001 1056750
005 2017-03-07
008 2015 bl uuuu u00u1 u #d
100 1 $aGARCIA, J.P
245 $aComparative Neuropathology of Ovine Enterotoxemia Produced by Clostridium perfringens Type D Wild-Type Strain CN1020 and Its Genetically Modified Derivatives.$h[electronic resource]
260 $c2015
520 $aAbstract Clostridium perfringens type D causes enterotoxemia in sheep and goats. The disease is mediated by epsilon toxin (ETX), which affects the cerebrovascular endothelium, increasing vascular permeability and leading to cerebral edema. In the present study, we compared the distribution and severity of the cerebrovascular changes induced in lambs by C. perfringens type D strain CN1020, its isogenic etx null mutant, and the ETX-producing complemented mutant. We also applied histochemical and immunohistochemical markers to further characterize the brain lesions induced by ETX. Both ETX-producing strains induced extensive cerebrovascular damage that did not differ significantly between each other in nature, neuroanatomic distribution, or severity. By contrast, lambs inoculated with the etx mutant or sterile, nontoxic culture medium did not develop detectable brain lesions, confirming that the neuropathologic effects observed in these infections are dependent on ETX production. Lambs treated with the wild-type and complemented strains showed perivascular and mural vascular edema, as well as serum albumin extravasation, particularly severe in the cerebral white matter, midbrain, medulla oblongata, and cerebellum. Brains of animals inoculated with the ETX-producing strains showed decreased expression of glial fibrillary acidic protein and increased expression of aquaporin-4 in the end-feet processes of the astrocytes around blood vessels. Early axonal injury was demonstrated with anti?amyloid precursor protein immunohistochemistry. Perivascular accumulation of macrophages/microglia with intracytoplasmic albumin globules was also observed in these animals. This study demonstrates that ETX is responsible for the major cerebrovascular changes in C. perfringens type D?induced disease.
650 $aENFERMEDADES DE LOS ANIMALES
700 1 $aGIANNITTI, F.
700 1 $aFINNIE, J.W.
700 1 $aMANAVIS, J. .
700 1 $aBEINGESSER, J.
700 1 $aADAMS ,V.
700 1 $aROOD, J.I.
700 1 $aUZAL, F.A.
773 $tVeterinary Pathology, 2015$gv.52.n.6. p.1250-1253, 2015.
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Registro original : |
INIA La Estanzuela (LE) |
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Registro completo
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Biblioteca (s) : |
INIA Tacuarembó. |
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Fecha actual : |
21/02/2014 |
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Actualizado : |
21/05/2018 |
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Tipo de producción científica : |
Documentos |
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Autor : |
SILVEIRA, C.; MONTOSSI, F.; LUZARDO, S.; SAN JULIÁN, R.; DE BARBIERI, I.; BOTTERO, D.; PERDOMO, G. |
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Afiliación : |
CAROLINA INES SILVEIRA ROJAS, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; FABIO MARCELO MONTOSSI PORCHILE, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; SANTIAGO FELIPE LUZARDO VILLAR, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; ROBERTO SAN JULIAN SANCHEZ, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; LUIS IGNACIO DE BARBIERI ETCHEBERRY, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; SERGIO DANIEL BOTTERO REGGI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
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Título : |
Efecto de la carga animal y del tipo de suplemento sobre la performance animal y calidad de canal y carne de corderos pesados Corriedale y sus cruzas Merino Dohne, pastoreando una pastura mezcla de Trifolium pratense y Cichorium intybus. |
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Fecha de publicación : |
2010 |
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Fuente / Imprenta : |
ln: INIA Tacuarembó. Unidad Experimental Glencoe. Día de campo, Glencoe, 10 setiembre 2010, Paysandú, Uruguay. Pasturas y producción animal. Tacuarembó (Uruguay): INIA, 2010. |
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Páginas : |
p. 17-20 |
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Serie : |
(INIA Serie Actividades de Difusión ; 619) |
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Idioma : |
Español |
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Contenido : |
Objetivos: Evaluar el efecto del tipo de suplemento y la carga animal sobre la performance animal y calidad de canal y carne de corderos pesados Corriedale puros y cruza Corriedale con Merino Dohne. - Evaluar el efecto del tipo de suplemento sobre la performance animal y calidad de canal y carne. - Evaluar el efecto de la carga sobre la performance animal y calidad de canal y carne. - Evaluar el efecto de los factores mencionados sobre la productitividad y valor nutritivo de la base forrajera que se utiliza. - Disponer de coeficientes biológicos para la evaluación económica de las alternativas propuestas. |
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Palabras claves : |
AFRECHILLO DE ARROZ; CARGA ANIMAL; CORDERO PESADO; SUPLEMENTOS. |
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Thesagro : |
FORRAJES; PRODUCCION ANIMAL; SUELO BASALTICO. |
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Asunto categoría : |
L01 Ganadería |
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URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/9689/1/SAD619p17-20.pdf
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Marc : |
LEADER 01732naa a2200301 a 4500
001 1026068
005 2018-05-21
008 2010 bl uuuu u00u1 u #d
100 1 $aSILVEIRA, C.
245 $aEfecto de la carga animal y del tipo de suplemento sobre la performance animal y calidad de canal y carne de corderos pesados Corriedale y sus cruzas Merino Dohne, pastoreando una pastura mezcla de Trifolium pratense y Cichorium intybus.
260 $c2010
300 $ap. 17-20
490 $a(INIA Serie Actividades de Difusión ; 619)
520 $aObjetivos: Evaluar el efecto del tipo de suplemento y la carga animal sobre la performance animal y calidad de canal y carne de corderos pesados Corriedale puros y cruza Corriedale con Merino Dohne. - Evaluar el efecto del tipo de suplemento sobre la performance animal y calidad de canal y carne. - Evaluar el efecto de la carga sobre la performance animal y calidad de canal y carne. - Evaluar el efecto de los factores mencionados sobre la productitividad y valor nutritivo de la base forrajera que se utiliza. - Disponer de coeficientes biológicos para la evaluación económica de las alternativas propuestas.
650 $aFORRAJES
650 $aPRODUCCION ANIMAL
650 $aSUELO BASALTICO
653 $aAFRECHILLO DE ARROZ
653 $aCARGA ANIMAL
653 $aCORDERO PESADO
653 $aSUPLEMENTOS
700 1 $aMONTOSSI, F.
700 1 $aLUZARDO, S.
700 1 $aSAN JULIÁN, R.
700 1 $aDE BARBIERI, I.
700 1 $aBOTTERO, D.
700 1 $aPERDOMO, G.
773 $tln: INIA Tacuarembó. Unidad Experimental Glencoe. Día de campo, Glencoe, 10 setiembre 2010, Paysandú, Uruguay. Pasturas y producción animal. Tacuarembó (Uruguay): INIA, 2010.
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